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Clonal expansion and diversification of cancer-associated mutations in endometriosis and normal endometrium

Cell-culture (3T3-L1 adipocytes) 5-Amino-1MQ at 30 M strongly reduced 1-MNA levels in mouse fat cells, confirming NNMT inhibition (Neelakantan et al., Biochemical Pharmacology, 2018)

Conclusions This study method effectively identified an Alzheimers disease marker and compounds targeting the marker and interconnected biological processes by use of multiple computational approaches

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